Pd/Chiral Phosphoric Acid-Enabled Asymmetric Intramolecular Double C–H Activation Reaction for the Synthesis of <i>P</i>-Stereogenic Benzophosphole Oxides
A Pd-catalyzed intramolecular asymmetric double C-H activation reaction was reported, and a BINOL skeleton-based chiral phosphoric acid (CPA) was identified as a suitable ligand for this transformation. A broad range of <i>P</i>-stereogenic benzophosphole oxides were synthesized in moderate to excellent yield with high levels of enantioselectivity (≤96% ee).
Authors
- Shaobai Yan
- Wei‐Liang Duan (ORCID: https://orcid.org/0000-0003-2791-1931)
- Zhen Li (ORCID: https://orcid.org/0000-0001-8037-4245)
- Shuwei Zhang (ORCID: https://orcid.org/0000-0001-8204-192X)
- Hu XianQi
Institutions
- Inner Mongolia University (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-02-03
- DOI
- https://doi.org/10.1021/acs.orglett.4c04853
- Citations
- 3
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- National Natural Science Foundation of China
- Inner Mongolia University
- Yangzhou University