Validation of a Demography-Based Adaptive QT Correction Formula Using Pediatric and Adult Datasets Acquired From Humans and Guinea Pigs
The demography-based QTcAd formula showed superior performance across human and guinea pig age groups, which may enhance the efficacy of rate-corrected K.M.M. for cardiovascular disease diagnosis, risk stratification, and drug safety testing in children and adults.
Authors
- Charles I. Berul (ORCID: https://orcid.org/0000-0002-9604-7369)
- Michael J. Shattock (ORCID: https://orcid.org/0000-0001-6242-7585)
- K. H. McLean
- Nikki Gillum Posnack (ORCID: https://orcid.org/0000-0002-3880-7200)
- Grace Anderson (ORCID: https://orcid.org/0000-0001-6374-1445)
- Kazi T. Haq
Institutions
- Children's National (US)
- George Washington University (US)
- British Heart Foundation (GB)
Publication Details
- Journal
- Circulation Arrhythmia and Electrophysiology
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1161/circep.124.013237
- Citations
- 2
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 2.78