Cerebral Microhemorrhages in Children With Congenital Heart Disease: Prevalence, Risk Factors, and Association With Neurodevelopmental Outcomes
CMH are common imaging findings in infants with congenital heart disease, particularly after cardiopulmonary bypass conferring adverse impact on neurodevelopmental outcomes at 18 months. Longer duration of cardiopulmonary bypass and extracorporeal membrane oxygenation use demonstrated greatest risk for developing CMH. However, the presence of CMH on preoperative scans indicates yet unidentified nonperioperative risk factors. Neuroprotective strategies to mitigate CMH risk may improve neurodevelopmental outcomes in this vulnerable population.
Authors
- Arastoo Vossough (ORCID: https://orcid.org/0000-0003-1346-427X)
- Wesley B. Baker (ORCID: https://orcid.org/0000-0002-3025-6061)
- Tiffany S. Ko (ORCID: https://orcid.org/0000-0002-5113-0310)
- J. William Gaynor (ORCID: https://orcid.org/0000-0001-7955-5604)
- Jharna Jahnavi
- Daniel J. Licht (ORCID: https://orcid.org/0000-0002-4080-843X)
- Jake Breimann
- Marin Jacobwitz (ORCID: https://orcid.org/0000-0002-9489-6594)
- Rui Xiao (ORCID: https://orcid.org/0000-0002-2727-8171)
- Alexander L. Schmidt (ORCID: https://orcid.org/0000-0003-4328-9513)
- Brian R. White (ORCID: https://orcid.org/0000-0001-5196-2339)
- Evelyn K. Shih (ORCID: https://orcid.org/0000-0002-8455-0231)
- Kristen N. Andersen (ORCID: https://orcid.org/0000-0001-6702-7097)
- Sicong Yao
Institutions
- Children's Hospital of Philadelphia (US)
- Children's National (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-02-03
- DOI
- https://doi.org/10.1161/jaha.123.035359
- Citations
- 3
- Primary Topic
- Congenital Heart Disease Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- Children's Hospital of Philadelphia
- June and Steve Wolfson Family Foundation
- National Institutes of Health