CAR-CIK vs. CAR-T: benchmarking novel cytokine-induced killer cells as solid tumor immunotherapy in ErbB2+ rhabdomyosarcoma
Our results demonstrate that CAR-CIK cells are at least equipotent to CAR-T cells. Combined with their favorable safety profile and allogeneic applicability, these findings position CAR-CIK cells as promising immune effectors for solid tumors.
Authors
- Christian Münch (ORCID: https://orcid.org/0000-0003-3832-090X)
- Hermann Kreyenberg (ORCID: https://orcid.org/0000-0003-3575-9175)
- Sabine Harenkamp
- Evelyn Ullrich (ORCID: https://orcid.org/0000-0001-8530-1192)
- Peter Bader (ORCID: https://orcid.org/0000-0003-4554-0265)
- Jan‐Henning Klusmann (ORCID: https://orcid.org/0000-0002-1070-0727)
- Catrin Heim (ORCID: https://orcid.org/0000-0001-7581-3354)
- Winfried S. Wels (ORCID: https://orcid.org/0000-0001-9858-3643)
- Elise Gradhand (ORCID: https://orcid.org/0000-0003-3143-0487)
- Eva Rettinger
- Philipp Wendel (ORCID: https://orcid.org/0000-0001-5844-1587)
- Sebastian E. Koschade (ORCID: https://orcid.org/0000-0001-5770-1279)
- Halvard Bönig (ORCID: https://orcid.org/0000-0003-0088-2675)
- Laura M. Moser (ORCID: https://orcid.org/0000-0002-1241-5137)
- Meike Vogler (ORCID: https://orcid.org/0000-0003-2650-586X)
- Süleyman Bozkurt
- Michael Merker (ORCID: https://orcid.org/0000-0002-6295-1309)
Institutions
- Goethe University Frankfurt (DE)
- University of Washington (US)
- Technische Universität Darmstadt (DE)
- Institute of Clinical Cancer Research (DE)
- Georg Speyer Haus (DE)
- Cardio-Pulmonary Institute (DE)
- Frankfurt Cancer Institute (DE)
- Deutsches Konsortium für Translationale Krebsforschung (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-02-03
- DOI
- https://doi.org/10.3389/fimmu.2025.1485817
- Citations
- 8
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 8.36
Funders
- Deutsche Forschungsgemeinschaft
- Else Kröner-Fresenius-Stiftung
- Deutsche Krebshilfe
- Dr. Mildred Scheel Stiftung für Krebsforschung
- Deutsche Kinderkrebsstiftung