Vascular Contractility Relies on Integrity of Progranulin Pathway: Insights Into Mitochondrial Function
Our findings suggest that PGRN preserves the vascular contractility via regulating mitophagy flux, mitochondrial activity and dynamics, and redox signaling. Therefore, loss of PGRN function appears as a pivotal risk factor in cardiovascular disease.
Authors
- Thiago Bruder‐Nascimento (ORCID: https://orcid.org/0000-0001-5671-318X)
- Juliano Alves (ORCID: https://orcid.org/0000-0002-6555-5547)
- Rafael Menezes da Costa (ORCID: https://orcid.org/0000-0002-5174-5710)
- Eric S. Goetzman (ORCID: https://orcid.org/0000-0001-9476-309X)
- Shubhnita Singh (ORCID: https://orcid.org/0000-0002-1835-2317)
- Sivakama S. Bharathi
- Ariane Bruder
Institutions
- Children's Hospital of Philadelphia (US)
- University of Pittsburgh (US)
- Children's Hospital of Pittsburgh (US)
- University of Pennsylvania (US)
- University of South Alabama (US)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-02-03
- DOI
- https://doi.org/10.1161/jaha.124.037640
- Citations
- 5
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 6.95
Funders
- American Heart Association
- National Heart, Lung, and Blood Institute