Cardiac Gene Therapy With Phosphodiesterase 2A Limits Remodeling and Arrhythmias in Mouse Models of Heart Failure
Cardiac gene therapy with PDE2A limits left ventricle remodeling, dysfunction, and arrhythmias evoked by catecholamines, providing evidence that increasing PDE2A activity acutely could prevent progression toward heart failure.
Authors
- Flavien Charpentier (ORCID: https://orcid.org/0000-0002-5057-0998)
- Agnès Hivonnait
- Françoise Mercier‐Nomé (ORCID: https://orcid.org/0000-0002-9515-7232)
- Alessandra Ghigo (ORCID: https://orcid.org/0000-0002-1193-5296)
- Jean Piero Margaria (ORCID: https://orcid.org/0000-0002-2435-7499)
- Jérôme Leroy (ORCID: https://orcid.org/0000-0001-5168-0606)
- Vincent Algalarrondo (ORCID: https://orcid.org/0000-0001-5971-1235)
- Victor X. Jin (ORCID: https://orcid.org/0000-0002-8765-3471)
- Grégoire Vandecasteele (ORCID: https://orcid.org/0000-0002-4046-4171)
- Rodolphe Fischmeister (ORCID: https://orcid.org/0000-0003-2086-9865)
- Emilio Hirsch (ORCID: https://orcid.org/0000-0002-9073-6024)
- Aurélia Bourcier (ORCID: https://orcid.org/0000-0003-3462-9512)
- Delphine Mika (ORCID: https://orcid.org/0000-0003-2895-7173)
- Audrey Varin (ORCID: https://orcid.org/0009-0000-1709-2333)
- Rima Kamel
Institutions
- Centre National de la Recherche Scientifique (FR)
- Vita-Salute San Raffaele University (IT)
- Inserm (FR)
- Université Paris-Saclay (FR)
- Institut du Thorax (FR)
- Laboratory Signaling and Cardiovascular Pathophysiology (FR)
- Nantes Université (FR)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-02-03
- DOI
- https://doi.org/10.1161/jaha.124.037343
- Primary Topic
- Phosphodiesterase function and regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00