Targeted inhibition of the PTEN/PI3K/AKT pathway by YSV induces cell cycle arrest and apoptosis in oral squamous cell carcinoma
YSV inhibited the progression of OSCC by promoting cell cycle arrest and apoptosis through the regulation of the PTEN/PI3K/AKT signaling pathway. The combination of YSV and PI3K inhibitors, such as LY294002, exhibited enhanced anti-tumor activity, suggesting potential therapeutic strategies for OSCC treatment.
Authors
- Qian Gao (ORCID: https://orcid.org/0000-0003-3771-1861)
- Yi‐Hua Liao (ORCID: https://orcid.org/0000-0002-4434-3780)
- Xinxin Li (ORCID: https://orcid.org/0000-0003-1840-994X)
- Lin Qiu (ORCID: https://orcid.org/0000-0003-3192-3070)
- Cuiying Li (ORCID: https://orcid.org/0000-0002-7045-0838)
Institutions
- Beijing University of Chinese Medicine (CN)
- Peking University (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- National Clinical Research (US)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-02-03
- DOI
- https://doi.org/10.1186/s12967-025-06169-z
- Citations
- 2
- Primary Topic
- PI3K/AKT/mTOR signaling in cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Innovative Research Group Project of the National Natural Science Foundation of China
- National Natural Science Foundation of China