Cytotoxicity and molecular docking analysis of phytochemicals from Vallisneria spiralis with protein target 3CZH in breast cancer management

The anticancer potential of <i>Vallisneria spiralis Linnaeus</i> (<i>Vallisneria spiralis L</i>.) for human breast cancer management is of interest. <i>In vitro</i> shows that increasing concentrations of <i>Vallisneria spiralis</i> silver nanoparticles (AgNPs) and iron oxide nanoparticles (IONPs) resulted in greater cytotoxicity against MCF-7 breast cancer cells. The antioxidant potential of <i>Vallisneria spiralis L</i>. was assessed using 2-diphenyl-1-picryl-hydroxyl (DPPH) radical scavenging assay. Further molecular docking analysis of phytocompounds from <i>Vallisneria spiralis L</i>. with the target protein (PDB ID: 3CZH) shows optimal binding features. Thus, cytotoxicity analysis of <i>Vallisneria spiralis</i> for breast cancer with molecular docking of its phytochemicals and a target protein 3CZH is reported for further consideration.