Controlled Quantum Well Formation on DNA-Wrapped Carbon Nanotubes via Peroxide-Mediated Aryl Diazonium Reduction
Quantum well defect-modified single-walled carbon nanotubes are nanomaterials with wide-ranging applications in biosensing, imaging, quantum computing, and catalysis. The most common method for covalent functionalization of nanotubes for biosensing applications involves reactions with aryl diazonium salts to generate sp<sup>3</sup> aryl defect sites, commonly followed by wrapping with single-stranded DNA for aqueous dispersion. We describe herein a rapid aryl diazonium functionalization reaction directly compatible with DNA-wrapped nanotubes, mediated by hydrogen peroxide. The reaction uses mild aqueous conditions at physiological pH and can be easily monitored in real-time via fluorescence analysis to control the degree of functionalization. Overall, this reaction greatly simplifies the production of covalently functionalized DNA-wrapped carbon nanotubes, expanding their potential for industrial and biomedical applications.
Authors
- Stanislav S. Piletsky (ORCID: https://orcid.org/0000-0001-6986-0787)
- Daniel A. Heller (ORCID: https://orcid.org/0000-0002-6866-0000)
- Erin Keblish
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- Cornell University (US)
- Weill Cornell Medicine (US)
Publication Details
- Journal
- Nano Letters
- Published
- 2025-02-03
- DOI
- https://doi.org/10.1021/acs.nanolett.4c06061
- Citations
- 8
- Primary Topic
- Carbon Nanotubes in Composites
- Type
- article
- Field-Weighted Citation Impact
- 4.14
Funders
- National Science Foundation
- Honorable Tina Brozman Foundation
- Memorial Sloan-Kettering Cancer Center
- Ovarian Cancer Research Alliance
- Commonwealth Foundation for Cancer Research Foundation
- Ara Parseghian Medical Research Fund
- Expect Miracles Foundation
- National Cancer Institute
- National Institute of Biomedical Imaging and Bioengineering
- Congressionally Directed Medical Research Programs