HACE1 protects against myocardial ischemia–reperfusion injury via inhibition of mitochondrial fission in mice
Collectively, our data show that myocardial I/RI is associated with HACE1 downregulation and Drp1 activation, causing cardiomyocytes to undergo cell death. Therefore, HACE1 could be a promising therapeutic target for the treatment of myocardial I/RI.
Authors
- Chen Chen (ORCID: https://orcid.org/0000-0002-6630-6438)
- Lei Gao (ORCID: https://orcid.org/0000-0002-9957-4527)
- Heng-Chen Yao (ORCID: https://orcid.org/0000-0003-0291-8723)
- Ying Sun (ORCID: https://orcid.org/0000-0002-2979-4735)
- Zhan-Wei Tang
- Bang-Xia Liu
- Meng Wang (ORCID: https://orcid.org/0000-0002-8168-8999)
- Zheng Juan
Institutions
- Shandong University (CN)
- Jinan Central Hospital (CN)
- Heze Municipal Hospital (CN)
- Liaocheng People's Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- BMC Cardiovascular Disorders
- Published
- 2025-02-03
- DOI
- https://doi.org/10.1186/s12872-024-04445-2
- Citations
- 4
- Primary Topic
- Cardiac Ischemia and Reperfusion
- Type
- article
- Field-Weighted Citation Impact
- 5.89
Funders
- Shandong University
- Natural Science Foundation of Shandong Province