Lower circulating mitochondrial DNA and increased mitokines suggest significant mitochondrial dysfunction in systemic lupus erythematosus with renal involvement
Our findings suggest that lower whole blood mtDNA/nucDNA ratio, a surrogate marker for mitochondrial dysfunction, reflects renal damage, while GDF-15 may also reflect disease activity in SLE. Further studies are needed to assess the clinical value of these markers as predictors for active lupus nephritis.
Authors
- Ashfaque A. Memon (ORCID: https://orcid.org/0000-0002-1081-3553)
- Anna Hedelius
- Manuel Pascual (ORCID: https://orcid.org/0000-0001-7747-1693)
- Camillo Ribi (ORCID: https://orcid.org/0000-0002-0446-9741)
- Kristina Sundquist (ORCID: https://orcid.org/0000-0001-8031-279X)
- Matthieu Halfon (ORCID: https://orcid.org/0000-0001-6560-3222)
Institutions
- Lund University (SE)
- University of Lausanne (CH)
Publication Details
- Journal
- Lupus Science & Medicine
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1136/lupus-2024-001368
- Citations
- 4
- Primary Topic
- GDF15 and Related Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 6.67
Funders
- Centre Hospitalier Universitaire Vaudois