Alcohol consumption, polygenic risk score, and the risk of colorectal neoplasia
High alcohol consumption and polygenic risk score have a major impact on the risk of advanced colorectal neoplasia. The estimated preventive impact of avoiding high alcohol consumption is as strong as the impact of having a substantially lower polygenic risk.
Authors
- Xuechen Chen (ORCID: https://orcid.org/0000-0002-7683-2933)
- Michael Hoffmeister (ORCID: https://orcid.org/0000-0002-8307-3197)
- Ruojin Fu (ORCID: https://orcid.org/0000-0003-3519-0046)
- Hermann Brenner (ORCID: https://orcid.org/0000-0002-6129-1572)
- Teresa Seum (ORCID: https://orcid.org/0009-0003-4475-0583)
Institutions
- Jinan University (CN)
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Heidelberg University (US)
Publication Details
- Journal
- JNCI Cancer Spectrum
- Published
- 2025-02-03
- DOI
- https://doi.org/10.1093/jncics/pkaf017
- Citations
- 1
- Primary Topic
- Alcohol Consumption and Health Effects
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Deutsche Krebshilfe