Comparative transcriptomics reveal stage-dependent parasitic adaptations in the myxozoan Sphaerospora molnari
In order to address the threat posed by myxozoans to both cultured fish species and wild stocks, it is imperative to deepen our understanding of their genetics. Sphaerospora molnari offers an appealing model for stage-specific transcriptomic profiling and for identifying differentially expressed key functional gene groups related to parasite development. We identified genes that are thus far unique to S. molnari, which reveal their evolutionary novelty and likely role as adaptations to specific host niches. In addition, we describe the pathogenicity-associated genetic toolbox of S. molnari and discuss the implications of our discoveries for disease control by shedding light on specific targets for potential intervention strategies.
Authors
- Martin Kolísko (ORCID: https://orcid.org/0000-0003-0600-1867)
- Jiří Kyslík (ORCID: https://orcid.org/0000-0002-0006-1343)
- Astrid S. Holzer (ORCID: https://orcid.org/0000-0002-4916-3172)
- Alena Lövy (ORCID: https://orcid.org/0000-0003-1050-0837)
- Monika M Wiśniewska (ORCID: https://orcid.org/0000-0003-1530-7833)
- Gema Alama-Bermejo (ORCID: https://orcid.org/0000-0002-6452-6154)
- Anush Kosakyan (ORCID: https://orcid.org/0000-0001-6487-8304)
Institutions
- University of Modena and Reggio Emilia (IT)
- Sewanee: The University of the South (US)
- University of Veterinary Medicine Vienna (AT)
- National Australia Bank (AU)
- University of South Bohemia in České Budějovice (CZ)
- Institute of Parasitology of the Slovak Academy of Sciences (SK)
- Institute of Parasitology (CZ)
- Czech Academy of Sciences, Biology Centre (CZ)
Publication Details
- Journal
- BMC Genomics
- Published
- 2025-02-03
- DOI
- https://doi.org/10.1186/s12864-025-11265-x
- Citations
- 2
- Primary Topic
- Myxozoan Parasites in Aquatic Species
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Grantová Agentura České Republiky