The OXT rs6133010 variant modulates susceptibility to psychiatric symptoms during withdrawal in patients with alcohol dependence
This study presents novel evidence that OXT rs6133010 specifically modulates psychiatric symptoms in AD. The G allele may heighten hostility and anxiety vulnerability during alcohol withdrawal. These findings emphasize considering environmental factors when studying and utilizing oxytocin therapeutically. Additionally, OXT may not directly act as an anxiolytic but instead regulates anxiety by modulating hostility.
Authors
- Yanlong Liu (ORCID: https://orcid.org/0000-0002-4790-7924)
- Guanghui Shen (ORCID: https://orcid.org/0000-0002-4253-695X)
- Yimin Kang
- Li Chen (ORCID: https://orcid.org/0000-0002-3472-7756)
- Fan Wang (ORCID: https://orcid.org/0000-0002-6106-4724)
- Wei Wang (ORCID: https://orcid.org/0000-0002-5868-835X)
- Kexin Wang (ORCID: https://orcid.org/0009-0004-8256-069X)
- Yu‐Hsin Chen (ORCID: https://orcid.org/0000-0002-7829-4008)
- Yuyu Wu (ORCID: https://orcid.org/0000-0002-8140-1652)
- Xinguang Luo
Institutions
- Peking University (CN)
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Yale University (US)
- Jinzhou Kangning Hospital (CN)
- Beijing HuiLongGuan Hospital (CN)
- Wenzhou City People's Hospital (CN)
- Inner Mongolia Medical University (CN)
Publication Details
- Journal
- BMC Psychiatry
- Published
- 2025-02-03
- DOI
- https://doi.org/10.1186/s12888-025-06529-5
- Citations
- 1
- Primary Topic
- Eating Disorders and Behaviors
- Type
- article
- Field-Weighted Citation Impact
- 2.31
Funders
- Opening Project of Zhejiang Provincial Top Key Discipline of Pharmaceutical Sciences
- Natural Science Foundation of Xinjiang
- Natural Science Foundation of Ningbo