BCL-XL Protects ASS1-Deficient Cancers from Arginine Starvation–Induced Apoptosis
The study identifies BCL-XL as a key factor limiting the efficacy of arginine starvation therapies. Combining BCL-XL inhibitors with arginine deprivation strategies may overcome this resistance and enhance therapeutic outcomes. These findings provide a strong preclinical rationale for testing this combination approach in phase 1 clinical trials for ASS1-deficient cancers.
Authors
- Brian Andrew Van Tine (ORCID: https://orcid.org/0000-0003-4572-6668)
- John S. Bomalaski (ORCID: https://orcid.org/0000-0002-9454-7271)
- Heather M. Benedict-Hamilton (ORCID: https://orcid.org/0009-0005-0385-4874)
- Toshinao Oyama (ORCID: https://orcid.org/0009-0007-2235-1409)
- William Ehrhardt (ORCID: https://orcid.org/0009-0008-3441-4646)
- Prashanta Kumar Panda (ORCID: https://orcid.org/0000-0001-6223-8071)
- Alliny C.S. Bastos (ORCID: https://orcid.org/0000-0003-0675-7250)
- Leonard C. Rogers (ORCID: https://orcid.org/0000-0002-2913-4454)
- Ethan Yang Chen (ORCID: https://orcid.org/0009-0008-7084-2509)
- Ana Carolina Paschoalini Mafra (ORCID: https://orcid.org/0000-0002-2547-9033)
- Caitlyn B. Brashears (ORCID: https://orcid.org/0000-0001-6007-6056)
- Carina Dehner (ORCID: https://orcid.org/0000-0001-5214-4813)
- Li Cao (ORCID: https://orcid.org/0000-0001-8612-1345)
- Maria Serra Bonet (ORCID: https://orcid.org/0009-0003-0109-9583)
Institutions
- St. Louis Children's Hospital (US)
- Washington University in St. Louis (US)
- Midwest Therapeutic Endoscopy (US)
- Polaris Group (United States) (US)
- Wuhan Union Hospital (CN)
- Plex Pharmaceuticals (United States) (US)
- Union Hospital (CN)
- Indiana University School of Medicine
- Huazhong University of Science and Technology (CN)
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-02-03
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-2548
- Citations
- 4
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.93
Funders
- Washington University in St. Louis
- Children's Discovery Institute
- National Institutes of Health
- Center for Cellular Imaging, Washington University
- National Cancer Institute