Carriers of Parkinson’s disease-linked SNCA Rep1 variant have greater non-motor decline: a 4 year follow up study

Alpha-synuclein gene promoter (SNCA Rep1) polymorphism has been linked to Parkinson's Disease (PD) susceptibility and motor symptom severity, but less is known about its longitudinal relationship with non-motor symptom severity. To address this gap, this is the first longitudinal study over 4 years investigating the relationship between Rep1 allele length and non-motor function amongst 208 early PD patients grouped into long (<i>n</i> = 111) vs. short (<i>n</i> = 97) Rep1 allele carriers. Long Rep1 carriers demonstrated faster decline in global cognition (<i>p</i> = 0.023) and increasing apathy (<i>p</i> = 0.027), with greater decline in attention and memory domains (<i>p</i> = 0.001), highlighting the utility of Rep1 polymorphism in stratifying patients at risk of non-motor symptom decline.

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Publication Details

Journal
Aging
Published
2025-02-03
DOI
https://doi.org/10.18632/aging.206196
Primary Topic
Parkinson's Disease Mechanisms and Treatments
Type
article
Field-Weighted Citation Impact
0.00

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article

Carriers of Parkinson’s disease-linked SNCA Rep1 variant have greater non-motor decline: a 4 year follow up study

Yi Jayne Tan, Shermyn Neo, Zheyu Xu, Adeline Su Lyn Ng et al.
Aging
Parkinson's Disease Mechanisms and Treatments
article

Carriers of Parkinson’s disease-linked SNCA Rep1 variant have greater non-motor decline: a 4 year follow up study

Yi Jayne Tan, Shermyn Neo, Zheyu Xu, Adeline Su Lyn Ng, Eng‐King Tan, Samuel Yong‐Ern Ng, Nicole Shuang Yu Chia, Louis C.S. Tan, Dede Liana Heng, Xinyi Choi, Seyed Ehsan Saffari, Yi Zhao, Wing Lok Au, Kay Yaw Tay, Ebonne Ng, Aarthi Santhanakrishnan
article en

Abstract

Alpha-synuclein gene promoter (SNCA Rep1) polymorphism has been linked to Parkinson's Disease (PD) susceptibility and motor symptom severity, but less is known about its longitudinal relationship with non-motor symptom severity. To address this gap, this is the first longitudinal study over 4 years investigating the relationship between Rep1 allele length and non-motor function amongst 208 early PD patients grouped into long (<i>n</i> = 111) vs. short (<i>n</i> = 97) Rep1 allele carriers. Long Rep1 carriers demonstrated faster decline in global cognition (<i>p</i> = 0.023) and increasing apathy (<i>p</i> = 0.027), with greater decline in attention and memory domains (<i>p</i> = 0.001), highlighting the utility of Rep1 polymorphism in stratifying patients at risk of non-motor symptom decline.

AgingVol. 17(2)
National University of Singapore (SG), Nanyang Technological University (SG), Singapore General Hospital (SG), Tan Tock Seng Hospital (SG), Duke-NUS Medical School (SG), National Neuroscience Institute (SG)
Medical Research Council, National Medical Research Council
Openalex Percentile: Top 97%
Parkinson's Disease Mechanisms and Treatments
DOIOpen Access PDFOpenAlex
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