Flow-Cytometric Quantification of Urine Kidney Epithelial Cells Specifically Reflects Tubular Damage in Acute Kidney Diseases
We propose that urinary CD227/CD326<sup>+</sup> TEC count is a specific, noninvasive marker for tubular injury in AKI. Our protocol provides a basis for a deeper phenotypic analysis of urinary TECs.
Authors
- Falk Hiepe (ORCID: https://orcid.org/0000-0003-3584-5292)
- Gabriela Riemekasten (ORCID: https://orcid.org/0000-0002-5406-2464)
- Valerie Langhans
- Philipp Enghard (ORCID: https://orcid.org/0000-0002-7254-3931)
- Paul A. Freund (ORCID: https://orcid.org/0000-0001-7164-5760)
- Jan Klocke (ORCID: https://orcid.org/0000-0002-7723-9234)
- Sabine Baumgart (ORCID: https://orcid.org/0000-0001-8861-0388)
- Sara Timm (ORCID: https://orcid.org/0000-0002-9937-4568)
- Luka Prskalo (ORCID: https://orcid.org/0009-0005-3566-1858)
- Emil Grothgar (ORCID: https://orcid.org/0000-0002-7742-8916)
- Leonie Wagner (ORCID: https://orcid.org/0009-0005-9322-0268)
- Jacob Kujat
- Diana Metzke
- Hannah Brand
- Adrian Schreiber (ORCID: https://orcid.org/0000-0003-1244-6379)
- Christopher Mark Skopnik (ORCID: https://orcid.org/0000-0002-6089-4769)
- Matthias Ochs (ORCID: https://orcid.org/0000-0002-0936-6979)
- Nina Goerlich
- Andreas Grützkau
Institutions
- Max Delbrück Center (DE)
- Humboldt-Universität zu Berlin (DE)
- German Rheumatism Research Centre (DE)
- German Center for Lung Research (DE)
- Jena University Hospital (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Freie Universität Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- Kidney International Reports
- Published
- 2025-02-03
- DOI
- https://doi.org/10.1016/j.ekir.2025.01.037
- Citations
- 2
- Primary Topic
- Acute Kidney Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 2.86
Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Berlin Institute of Health