IARC Workshop on the Key Characteristics of Carcinogens: Assessment of End Points for Evaluating Mechanistic Evidence of Carcinogenic Hazards
Consensus was reached on how to enhance the use of <i>in silico</i>, molecular, and cellular high-output and high-throughput data. In addition, approaches to integrate evidence across the KCs and opportunities to improve methodologies of mechanistic evaluation of cancer hazards were explored. The findings described herein and in a forthcoming IARC technical report will support future working groups of experts in reporting and interpreting results under the KCs framework within the <i>IARC Monographs</i> or in other contexts. https://doi.org/10.1289/EHP15389.
Authors
- Caterina Facchin (ORCID: https://orcid.org/0000-0003-1896-2155)
- Brad Reisfeld (ORCID: https://orcid.org/0000-0003-1310-1495)
- Fatiha El Ghissassi
- Jason M. Fritz (ORCID: https://orcid.org/0000-0002-6190-5968)
- Amy Wang (ORCID: https://orcid.org/0000-0002-6121-3937)
- Mary K. Schubauer‐Berigan (ORCID: https://orcid.org/0000-0002-5175-924X)
- Michael Korenjak (ORCID: https://orcid.org/0000-0003-3242-7968)
- Roger R. Reddel (ORCID: https://orcid.org/0000-0002-6302-6107)
- Aline de Conti
- Parveen Bhatti (ORCID: https://orcid.org/0000-0003-1709-1781)
- Roel C.H. Vermeulen (ORCID: https://orcid.org/0000-0003-4082-8163)
- David H. Phillips (ORCID: https://orcid.org/0000-0001-8509-3485)
- David M. DeMarini (ORCID: https://orcid.org/0000-0001-8357-7988)
- Sandra Pérdomo (ORCID: https://orcid.org/0000-0001-7740-8141)
- Dori R. Germolec (ORCID: https://orcid.org/0000-0003-4072-1956)
- Dinesh Kumar Barupal (ORCID: https://orcid.org/0000-0002-9954-8628)
- Kathryn Z. Guyton (ORCID: https://orcid.org/0000-0001-7825-1262)
- Jennifer Jinot
- Akram Ghantous (ORCID: https://orcid.org/0000-0002-2582-6402)
- Jiří Zavadil (ORCID: https://orcid.org/0000-0003-0640-5562)
- Elisa Pasqual (ORCID: https://orcid.org/0000-0001-7181-6160)
- William M. Gwinn
- Laure Dossus (ORCID: https://orcid.org/0000-0003-2716-5748)
- Federica Madia (ORCID: https://orcid.org/0000-0002-8438-0957)
- Danila Cuomo (ORCID: https://orcid.org/0000-0003-4752-5819)
- Lauren Zeise
- John Kaldor (ORCID: https://orcid.org/0000-0002-7639-4355)
- Weihsueh A. Chiu (ORCID: https://orcid.org/0000-0002-7575-2368)
- Eugenia Dogliotti
- Maria Helena Guerra Andersen (ORCID: https://orcid.org/0000-0001-9020-9462)
- Zdenko Herceg (ORCID: https://orcid.org/0000-0003-4109-3154)
- Martin van den Berg (ORCID: https://orcid.org/0000-0001-6239-6301)
- Paolo Vineis (ORCID: https://orcid.org/0000-0001-8935-4566)
- Roland Wedekind (ORCID: https://orcid.org/0000-0003-1364-7666)
- Kevin P. Cross (ORCID: https://orcid.org/0000-0002-2462-0533)
- Emily Watkins (ORCID: https://orcid.org/0000-0001-8342-7373)
- Shirisha Chittiboyina
- Gabrielle Rigutto (ORCID: https://orcid.org/0000-0002-9375-7381)
- N. Rothman
- Maurice Whelan (ORCID: https://orcid.org/0000-0002-7186-1663)
Institutions
- The University of Sydney (AU)
- Environmental Protection Agency (US)
- Ohio Environmental Protection Agency (US)
- Research Triangle Park Foundation (US)
- University of British Columbia (CA)
- King's College London (GB)
- Utrecht University (NL)
- National Academies of Sciences, Engineering, and Medicine (US)
- Istituto Superiore di Sanità (IT)
- European Commission (BE)
- Mitchell Institute (US)
- Imperial Valley College (US)
- National Research Centre for the Working Environment (DK)
- Centre international de recherche sur le cancer (FR)
- California Environmental Protection Agency (US)
- University of Roehampton (GB)
- Texas A&M University (US)
- Colorado State University (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Environmental Health Perspectives
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1289/ehp15389
- Citations
- 8
- Primary Topic
- Carcinogens and Genotoxicity Assessment
- Type
- article
- Field-Weighted Citation Impact
- 7.49
Funders
- U.S. Environmental Protection Agency
- World Health Organization
- National Institutes of Health
- Medical Research Council
- National Cancer Institute