Pd-Catalyzed/Ligand-Controlled Regioselective Asymmetric Hydrosulfonylation of Alkylallenes or Arylallenes
The metal-catalyzed hydrofunctionalization reaction of allenes is an efficient approach for the construction of new allyl compounds. This work described a palladium-catalyzed/ligand-controlled asymmetric hydrosulfonylation of simple alkylallenes and arylallenes in the presence of Pd<sub>2</sub>dba<sub>3</sub>. Using a Josiphos or Segphos ligand, the alkylallenes or arylallenes could render the corresponding branched chiral allylsulfones with high yields and high enantioselectivities up to 90% and 99% ee, respectively.
Authors
- Lingyan Liu (ORCID: https://orcid.org/0000-0001-5268-5986)
- Xiaohui Cao (ORCID: https://orcid.org/0000-0003-2094-2444)
- Jinghan Zou (ORCID: https://orcid.org/0000-0002-5039-4621)
- Jing Li (ORCID: https://orcid.org/0000-0003-3955-0010)
- Jing Wu (ORCID: https://orcid.org/0009-0000-8229-3422)
- Boyi Wang (ORCID: https://orcid.org/0000-0003-1071-2522)
- Weixing Chang
- Xinman Guo (ORCID: https://orcid.org/0009-0006-4837-7554)
Institutions
- Guangdong Pharmaceutical University (CN)
- Nankai University (CN)
- Collaborative Innovation Center of Chemical Science and Engineering Tianjin (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-02-03
- DOI
- https://doi.org/10.1021/acs.orglett.4c04259
- Citations
- 4
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 3.74
Funders
- National Natural Science Foundation of China