An Exosomal mRNA Urine Test for Detection and Risk Stratification of Human Kidney Transplant Rejection
Exosomal mRNA gene signatures identified patients with different stages and classes of rejection, including early stage and significant inflammation, enabling improved decision-making and patient management and reducing unnecessary biopsies by 45%. This represents a potential tool for risk stratification based on poor outcomes in patients with positive signatures.
Authors
- Johan Skog (ORCID: https://orcid.org/0000-0002-0926-1691)
- Nour K. Younis (ORCID: https://orcid.org/0000-0001-7693-6030)
- Helmut G. Rennke (ORCID: https://orcid.org/0000-0001-6442-3465)
- Areej Alghamdi
- Reza Abdi (ORCID: https://orcid.org/0000-0003-4789-5422)
- Kurt Franzen
- Sonia Kumar (ORCID: https://orcid.org/0000-0003-3630-3006)
- Elliot Hallmark
- Jamil Azzi (ORCID: https://orcid.org/0000-0002-6909-4645)
- Anil Chandraker (ORCID: https://orcid.org/0000-0001-9729-7717)
- Ahmad Halawi (ORCID: https://orcid.org/0000-0002-1197-7939)
- Christa Deban (ORCID: https://orcid.org/0000-0001-7853-7041)
- Anis J. Saad (ORCID: https://orcid.org/0000-0003-2402-2522)
- Richard N. Formica (ORCID: https://orcid.org/0000-0001-6452-3976)
- Shuran Xing
- Zhabiz Solhjou (ORCID: https://orcid.org/0000-0003-1296-220X)
- Rania El Fekih (ORCID: https://orcid.org/0000-0003-2156-9370)
- John Y. Choi (ORCID: https://orcid.org/0000-0002-9299-3921)
- James F. Markmann (ORCID: https://orcid.org/0000-0002-2762-6535)
- Astrid Weins (ORCID: https://orcid.org/0000-0002-1633-0245)
- Camila Macedo (ORCID: https://orcid.org/0000-0003-3624-1896)
- Siawosh K. Eskandari (ORCID: https://orcid.org/0000-0003-4867-4170)
- James Hurley
- Kassem Safa (ORCID: https://orcid.org/0000-0001-6447-3227)
- Leonardo V. Riella (ORCID: https://orcid.org/0000-0002-7636-3196)
- K. D. Cashman (ORCID: https://orcid.org/0000-0002-8472-1424)
- Tamara Merhej
- Matt McFaul
- Chris Ventura
- Brian C. Haynes
- Maribel Dagher
- Alexandre V Vlassov
- Soltan Al Chaar
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Hospital of the University of Pennsylvania (US)
- Yale University (US)
- Exosome Diagnostics (United States) (US)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- Kidney International Reports
- Published
- 2025-02-03
- DOI
- https://doi.org/10.1016/j.ekir.2025.01.036
- Citations
- 7
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 13.90
Funders
- Brigham and Women's Hospital
- Massachusetts General Hospital
- Yale University
- University of Pittsburgh