A Protein Kinase Cε/Protein Kinase D3 Signalling Axis Modulates RhoA Activity During Cytokinesis
PKD3 depletion leads to prolonged RhoA activity during cytokinesis, resulting in failed abscission and an increase in the number of multinucleated cells. This identifies a novel, previously unrecognised PKCε/PKD3 pathway involved in the modulation of cytokinesis.
Authors
- Michael Leitges (ORCID: https://orcid.org/0000-0003-4203-6995)
- Ursula Braun
Institutions
- Memorial University of Newfoundland (CA)
- Université Bourgogne Franche-Comté (FR)
Publication Details
- Journal
- Biomedicines
- Published
- 2025-02-03
- DOI
- https://doi.org/10.3390/biomedicines13020345
- Primary Topic
- Microtubule and mitosis dynamics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universitetet i Oslo
- Norges Forskningsråd
- Memorial University of Newfoundland