Small Molecules from Medicinal Plant Iris tectorum as Histidine Kinase Inhibitor to Resensitize β-Lactam-Resistant Escherichia coli
<i>Iris tectorum</i> extract may serve as an antibiotic adjuvant, restoring the sensitivity of antibiotic-resistant bacteria by inhibiting histidine kinase phosphorylation, thereby alleviating the problem of <i>Escherichia coli</i> resistance to β-lactam antibiotics.
Authors
- Zhangkai Xu
- Danlei Chen (ORCID: https://orcid.org/0009-0007-9475-6261)
- Xin Hong (ORCID: https://orcid.org/0000-0002-5348-4497)
- Dongqing Cheng (ORCID: https://orcid.org/0000-0003-2098-2817)
- Yinhuan Wang (ORCID: https://orcid.org/0000-0001-7423-377X)
- Zishu Liu (ORCID: https://orcid.org/0000-0001-6820-4593)
- Youqi Ji
- Qingyi Shao
- Zhendi Yu
Institutions
- Zhejiang Chinese Medical University (CN)
- ZheJiang Institute For Food and Drug Control (CN)
- Zhejiang University of Technology (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Molecules
- Published
- 2025-02-03
- DOI
- https://doi.org/10.3390/molecules30030663
- Citations
- 1
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- National Natural Science Foundation of China
- Zhejiang University
- Zhejiang Chinese Medical University