Celastrol promotes DNA damage and apoptosis in uterine corpus endometrial carcinoma via promotion of KAT2B-mediated RBPJ acetylation and repression of MCM4 transcription
These results underscore that Celastrol is a promising anti-cancer agent in UCEC with preferential anti-proliferative, pro-apoptotic and DNA damage effects through the KAT2B/RBPJ/MCM4 axis, and KAT2B is a promising therapeutic target for UCEC.
Authors
- Lipeng Pei (ORCID: https://orcid.org/0009-0006-5486-5108)
- Bin Xu (ORCID: https://orcid.org/0000-0002-8279-4304)
- Wenpeng Li (ORCID: https://orcid.org/0000-0003-2879-508X)
- Jingli Sun (ORCID: https://orcid.org/0009-0007-1641-2455)
- Yan Zhu (ORCID: https://orcid.org/0000-0002-0587-7966)
Institutions
- General Hospital of Shenyang Military Region (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-02-03
- DOI
- https://doi.org/10.1186/s10020-025-01082-z
- Citations
- 5
- Primary Topic
- Natural Compounds in Disease Treatment
- Type
- article
- Field-Weighted Citation Impact
- 11.91