Exosomal mir-126-3p derived from endothelial cells induces ion channel dysfunction by targeting RGS3 signaling in cardiomyocytes: a novel mechanism in Takotsubo cardiomyopathy
Our study is the first to reveal that exosomal miR-126-3p, originating from endothelial cells, contributes to ion channel dysfunction by regulating RGS3 signaling in cardiomyocytes. These findings provide new perspectives on the pathogenesis of TTC and suggest potential therapeutic targets for treatment.
Authors
- Mohammad Abumayyaleh (ORCID: https://orcid.org/0000-0002-4766-5523)
- Xuehui Fan (ORCID: https://orcid.org/0000-0001-9040-1155)
- Katherine Sattler
- Haojie Shi (ORCID: https://orcid.org/0000-0002-9767-4858)
- Yinuo Wang (ORCID: https://orcid.org/0000-0002-6653-6014)
- Thomas Stefan Worst (ORCID: https://orcid.org/0000-0001-5429-126X)
- Guoqiang Yang (ORCID: https://orcid.org/0000-0001-6202-7485)
- Gergana D. Dobreva (ORCID: https://orcid.org/0000-0002-4814-9416)
- İbrahim Akın (ORCID: https://orcid.org/0000-0002-4387-7115)
- Lukas Cyganek (ORCID: https://orcid.org/0000-0001-9120-1382)
- Ibrahim El‐Battrawy (ORCID: https://orcid.org/0000-0002-0139-1045)
- Daniel Duerschmied (ORCID: https://orcid.org/0000-0001-5249-4012)
- Katja Nitschke
- Xiaobo Zhou (ORCID: https://orcid.org/0000-0002-5895-0127)
- Bin Liao (ORCID: https://orcid.org/0000-0001-9797-7181)
- Philipp Nuhn
Institutions
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Southwest Medical University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
- German Center for Infection Research (DE)
- Universitätsmedizin Göttingen (DE)
- German Centre for Cardiovascular Research (DE)
- BG University Hospital Bergmannsheil Bochum (DE)
- University Medical Centre Mannheim (DE)
- Ruhr University Bochum (DE)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1186/s13287-025-04157-0
- Citations
- 7
- Primary Topic
- Takotsubo Cardiomyopathy and Associated Phenomena
- Type
- article
- Field-Weighted Citation Impact
- 9.72
Funders
- China Scholarship Council