Constructing a potential HLA haplo-homozygous induced pluripotent stem cell haplobank using data from an umbilical cord blood bank
The results suggested that at least some HLA-homozygous iPSC lines developed from Chinese individuals will not only be useful for covering the Chinese population but will also cover other Asian populations. A high-matching iPSC haplobank generated from umbilical CB units may be an economical and effective option in an allogeneic model of iPSC therapy.
Authors
- Qi Sheng (ORCID: https://orcid.org/0000-0001-9905-9448)
- Wei Zhang (ORCID: https://orcid.org/0000-0002-1324-2215)
- Faming Zhu (ORCID: https://orcid.org/0000-0002-1963-9176)
- Yanmin He (ORCID: https://orcid.org/0009-0007-2210-7262)
- Ji He (ORCID: https://orcid.org/0009-0000-4135-3732)
- Zhipan Wu (ORCID: https://orcid.org/0000-0002-8677-5928)
- Qigang Zhan (ORCID: https://orcid.org/0009-0006-6322-8602)
Institutions
- Blood Center of Zhejiang Province (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-02-03
- DOI
- https://doi.org/10.1186/s13287-025-04159-y
- Citations
- 2
- Primary Topic
- Pluripotent Stem Cells Research
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Zhejiang Province