Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD
Oxysterol accumulation in APOE4 and AD induced ABCA1 and caveolin-1 expression, contributing to lysosomal dysfunction and increased cellular senescence markers. This study provides novel insights into how cholesterol metabolism accelerates features of brain cellular senescence pathway and identifies therapeutic targets to mitigate these processes.
Authors
- Julia TCW (ORCID: https://orcid.org/0000-0002-3054-9374)
- Stan G. Louie (ORCID: https://orcid.org/0000-0001-5941-6690)
- Zoe Arvanitakis (ORCID: https://orcid.org/0000-0001-7477-8884)
- Bilal E. Kerman (ORCID: https://orcid.org/0000-0003-1106-3288)
- Yi Sun (ORCID: https://orcid.org/0000-0003-0516-9000)
- Cristelle Hugo
- Hussein N. Yassine (ORCID: https://orcid.org/0000-0002-2483-649X)
- Zhiheng Cai
- Qian Lü (ORCID: https://orcid.org/0000-0001-7271-5804)
- Alan T. Remaley (ORCID: https://orcid.org/0000-0001-5839-7280)
- Isaac Asante (ORCID: https://orcid.org/0000-0002-9628-3425)
- Jie Li (ORCID: https://orcid.org/0009-0002-2560-6749)
- Shaowei Wang (ORCID: https://orcid.org/0000-0002-1267-9554)
- Boyang Li (ORCID: https://orcid.org/0000-0003-2808-9986)
- Helena C. Chui (ORCID: https://orcid.org/0000-0003-1348-0931)
- David A. Bennett
- Dante Dikeman
Institutions
- Boston University (US)
- University of Southern California (US)
- Rush University Medical Center (US)
- National Institutes of Health (US)
- National Heart, Lung, and Blood Institute (US)
- Keck Graduate Institute (US)
Publication Details
- Journal
- Molecular Neurodegeneration
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1186/s13024-025-00802-7
- Citations
- 27
- Primary Topic
- Cholesterol and Lipid Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 54.17
Funders
- National Institute on Aging