Enhanced therapeutic effects of hypoxia-preconditioned mesenchymal stromal cell-derived extracellular vesicles in renal ischemic injury
Hypoxia significantly promotes the generation of MSC-EVs and enhances their therapeutic effects on renal IRI. The antioxidant stress effect induced by GSTO1 is identified as one of the most critical underlying mechanisms. Our findings highlight that hypoxia-pretreated MSC-EVs represent a novel and promising therapeutic strategy for renal IRI.
Authors
- Guangyuan Zhang (ORCID: https://orcid.org/0009-0009-1728-770X)
- Kexin Yang (ORCID: https://orcid.org/0000-0002-3630-1003)
- Fei Yuan (ORCID: https://orcid.org/0000-0002-9681-6367)
- Wei Gao (ORCID: https://orcid.org/0000-0001-7836-2851)
- Liang Zhong (ORCID: https://orcid.org/0000-0002-5932-7732)
- Ting Li (ORCID: https://orcid.org/0000-0001-6588-3017)
- Jie Liu (ORCID: https://orcid.org/0000-0003-0193-1336)
- Jie Sun (ORCID: https://orcid.org/0000-0002-6171-9479)
- Pengtao Liu
- Xiangyu Zou (ORCID: https://orcid.org/0000-0002-8420-2077)
Institutions
- Weifang Medical University (CN)
- Shanghai Jiao Tong University (CN)
- Shanghai Children's Medical Center (CN)
- Zhongda Hospital Southeast University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-02-03
- DOI
- https://doi.org/10.1186/s13287-025-04166-z
- Citations
- 19
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 15.31
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province
- Taishan Scholar Foundation of Shandong Province
- Weifang University of Science and Technology
- Shanghai Pudong New Area Health Commission