Intranasal delivery of hMSC-derived supernatant for treatment of ischemic stroke by inhibiting the pro-inflammatory polarization of neutrophils
Intranasal delivery of hMSC-L and hMSC-M effectively ameliorates cerebral ischemic injury in mice, comparable to traditional administration routes like intravenous delivery. Treatment with hMSC-L and hMSC-M enhances the PPAR-γ/STAT6/SOCS1 pathway and improves the neuroinflammatory response post-stroke by increasing N2 neutrophil infiltration. These results provide a theoretical basis for a deeper understanding of the mechanisms of stem cell therapy and for exploring suitable delivery pathways of stem cell treatment.
Authors
- Wenkang Jiang
- Hulun Li (ORCID: https://orcid.org/0000-0003-2501-6861)
- Xiujuan Lang (ORCID: https://orcid.org/0009-0007-1790-0266)
- Xijun Liu (ORCID: https://orcid.org/0000-0002-2624-6901)
- Yanting Lei (ORCID: https://orcid.org/0009-0008-6963-856X)
- Xiaobing Fu (ORCID: https://orcid.org/0000-0002-2465-1700)
- Ning Wang (ORCID: https://orcid.org/0000-0002-5206-1636)
- Rui Li (ORCID: https://orcid.org/0000-0001-8317-621X)
- Yumei Liu (ORCID: https://orcid.org/0000-0001-7022-2467)
- Miao Hao (ORCID: https://orcid.org/0000-0002-8386-2145)
- Haoran Ren (ORCID: https://orcid.org/0000-0002-1848-9188)
- Jinyi Liu (ORCID: https://orcid.org/0000-0003-1803-7752)
- Yixiang Jiang (ORCID: https://orcid.org/0000-0001-5690-2116)
Institutions
- Fujian Medical University (CN)
- Harbin Medical University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1186/s13287-025-04172-1
- Citations
- 9
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 7.25
Funders
- National Natural Science Foundation of China