hBMSC-EVs alleviate weightlessness-induced skeletal muscle atrophy by suppressing oxidative stress and inflammation
Our findings indicate that hBMSC-EVs are capable of inhibiting excessive activation of the UPS and autophagy lysosome pathway, suppressing oxidative stress and inflammatory response, reversing muscle fiber type transformation, effectively delaying hindlimb unloading-induced muscle atrophy and enhancing muscle function. Our study has further advanced the understanding of the molecular mechanism underlying muscle atrophy in weightlessness and has demonstrated the protective effect of hBMSC-EVs on muscle atrophy.
Authors
- Mengyuan Chang (ORCID: https://orcid.org/0009-0001-2098-6458)
- Hualin Sun (ORCID: https://orcid.org/0000-0003-1889-1561)
- Zihui Gao
- Jin Xu (ORCID: https://orcid.org/0000-0002-2942-8604)
- Boya Liu (ORCID: https://orcid.org/0000-0002-8844-8605)
- Bingqian Chen (ORCID: https://orcid.org/0009-0004-1044-2192)
- Yuntian Shen (ORCID: https://orcid.org/0000-0002-5145-4761)
- Wei Wang (ORCID: https://orcid.org/0000-0002-6907-1697)
- Feng Xu (ORCID: https://orcid.org/0000-0003-4579-8557)
- Xinlei Yao (ORCID: https://orcid.org/0009-0002-7256-7316)
- Ruiqi Liu (ORCID: https://orcid.org/0009-0003-9113-7327)
- Yanan Ji (ORCID: https://orcid.org/0000-0002-1179-0381)
Institutions
- Nantong University (CN)
- Soochow University (CN)
- Affiliated Hospital of Nantong University (CN)
- Ministry of Education (IR)
- Second People's Hospital of NanTong (CN)
- Changshu No.1 People's Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1186/s13287-025-04175-y
- Citations
- 12
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 9.67
Funders
- Jiangsu Commission of Health
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province