Metformin exerted tumoricidal effects on colon cancer tumoroids via the regulation of autophagy pathway
Different shared autophagy/apoptosis genes were modulated in CRC tumoroids after MTF treatment coinciding with both typical necrotic and apoptotic cells within the tumoroid structure. MTF can inhibit the integrity and proliferation of CRC tumoroids in dose-dependent manner.
Authors
- Çığır Biray Avcı (ORCID: https://orcid.org/0000-0001-8251-4520)
- Fatemeh Sadeghsoltani
- Sanya Haiaty (ORCID: https://orcid.org/0000-0002-1784-4926)
- Ahad Bazmani (ORCID: https://orcid.org/0000-0003-2301-0546)
- Marziyeh Sadat Moslehian
- Roya Shabkhizan
- Leila Sabour Takanlou (ORCID: https://orcid.org/0000-0002-6361-7150)
- Arezoo Rezaie Nezhad Zamani
- Maryam Sabour Takanlou (ORCID: https://orcid.org/0000-0002-1590-4833)
- Reza Rahbarghazi (ORCID: https://orcid.org/0000-0003-3864-9166)
- Mahdi Mahdipour
Institutions
- Tabriz University of Medical Sciences (IR)
- Ege University (TR)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1186/s13287-025-04174-z
- Citations
- 5
- Primary Topic
- Metabolism, Diabetes, and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 4.03
Funders
- Tabriz University of Medical Sciences
- University of Tabriz