Single-nucleotide polymorphisms in dizygotic twin ovine fetuses are associated with discordant responses to antenatal steroid therapy
Twin fetal responses and ANS tissue levels were comparable with those from singleton fetuses in earlier studies. Twin ovine fetuses thus benefit from ANS in a similar manner to singleton fetuses, and a larger dose of betamethasone is not required. Assuming no difference in input from the placental or maternal compartments, fetal lung responses to ANS therapy in dizygotic twin preterm lambs are dependent on the fetus itself. These data suggest a potential heritable role in determining ANS responsiveness.
Authors
- Sebastián E. Illanes (ORCID: https://orcid.org/0000-0001-5433-9315)
- Gokce Oguz (ORCID: https://orcid.org/0000-0003-1044-7204)
- Yuki Takahashi (ORCID: https://orcid.org/0000-0002-6711-8295)
- Liang Shen (ORCID: https://orcid.org/0000-0001-7976-668X)
- Erin L. Fee (ORCID: https://orcid.org/0000-0003-1240-8006)
- Yusaku Kumagai (ORCID: https://orcid.org/0000-0003-3253-9601)
- Masatoshi Saito (ORCID: https://orcid.org/0000-0001-8122-6623)
- Michael W. Clarke (ORCID: https://orcid.org/0000-0002-9639-5670)
- Adaikalavan Ramasamy (ORCID: https://orcid.org/0000-0002-7598-2892)
- John P. Newnham (ORCID: https://orcid.org/0000-0001-9983-7457)
- Haruo Usuda (ORCID: https://orcid.org/0000-0002-9334-8086)
- Tsukasa Takahashi (ORCID: https://orcid.org/0000-0002-5567-4091)
- Andrew Ritchie
- Mahesh Choolani (ORCID: https://orcid.org/0000-0001-8336-0973)
- Sean W. D. Carter (ORCID: https://orcid.org/0009-0000-3441-3186)
- Hideyuki Ikeda (ORCID: https://orcid.org/0009-0005-0707-6125)
- Demelza J. Ireland (ORCID: https://orcid.org/0000-0002-8763-3542)
- Sara Ritchie
- Matthew W. Kemp (ORCID: https://orcid.org/0000-0001-9662-5029)
- Binny Priya Sesurajan
- Alan Jobe
Institutions
- Agency for Science, Technology and Research (SG)
- Cincinnati Children's Hospital Medical Center (US)
- National University of Singapore (SG)
- Murdoch University (AU)
- The University of Western Australia (AU)
- Universidad de Los Andes, Chile (CL)
- Tohoku University Hospital (JP)
- Children's Hospital of Chongqing Medical University (CN)
- University of Cincinnati (US)
- Genome Institute of Singapore (SG)
- Chongqing Medical University (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1186/s12916-025-03910-9
- Citations
- 4
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 6.07
Funders
- Women and Infants Research Foundation