O-GlcNAcylation attenuates ischemia-reperfusion-induced pulmonary epithelial cell ferroptosis via the Nrf2/G6PDH pathway
In summary, we revealed that O-GlcNAcylation could protect against I/R lung injury by reducing ferroptosis sensitivity via the Nrf2/G6PDH pathway. Our work will provide a new basis for clinical therapeutic strategies for pulmonary ischemia-reperfusion-induced acute lung injury.
Authors
- Songping Xie (ORCID: https://orcid.org/0000-0001-6519-6903)
- Rui Xuan
- Hexiao Tang (ORCID: https://orcid.org/0009-0006-6676-0426)
- Liuqing Yang (ORCID: https://orcid.org/0000-0001-8348-5928)
- Dawei Xu (ORCID: https://orcid.org/0000-0003-2003-2993)
- Jin Wang (ORCID: https://orcid.org/0000-0003-3402-6658)
- Xinyi Li (ORCID: https://orcid.org/0000-0002-8415-0385)
- Pengfei Xu (ORCID: https://orcid.org/0000-0003-2793-9723)
Institutions
- Wuhan University (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- BMC Biology
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1186/s12915-025-02126-w
- Citations
- 10
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 15.18