Association of accelerated phenotypic aging, genetic risk, and lifestyle with progression of type 2 diabetes: a prospective study using multi-state model
PhenoAgeAccel was consistently associated with an increased risk of all transitions in T2D progression. It has the potential to be combined with genetic risk to identify early T2D incidence risk and may guide interventions throughout T2D progression while tracking their effectiveness.
Authors
- Yifang Huang (ORCID: https://orcid.org/0009-0008-4643-7730)
- Yongfu Yu (ORCID: https://orcid.org/0000-0003-4208-9480)
- Yahang Liu (ORCID: https://orcid.org/0000-0003-1110-8183)
- Kecheng Wei (ORCID: https://orcid.org/0000-0002-2571-3993)
- Ye Yao (ORCID: https://orcid.org/0000-0001-6240-9539)
- Ruilang Lin
- Guoyou Qin (ORCID: https://orcid.org/0000-0002-1413-3117)
- Lulu Pan (ORCID: https://orcid.org/0000-0001-7724-9240)
- Chen Huang (ORCID: https://orcid.org/0009-0006-1235-3374)
Institutions
- Fudan University (CN)
- Ministry of Education (KR)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1186/s12916-024-03832-y
- Citations
- 19
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 22.12
Funders
- Natural Science Foundation of Shanghai
- National Natural Science Foundation of China
- Shanghai Rising-Star Program