Nickel/Photo-Cocatalyzed Cross-Coupling of Enol Silyl Ethers with α-Trifluoromethyl Bromides to Access β-CF<sub>3</sub>-Substituted Ketones
Herein, we introduce a nickel-photocatalyzed cross-coupling reaction between enol silyl ethers and CF<sub>3</sub>-substituted alkyl bromides. This method provides a streamlined approach for synthesizing a wide array of structurally diverse β-CF<sub>3</sub>-substituted ketones, achieving favorable yields under mild conditions. The practicality of this methodology is further underscored by its successful application in the late-stage functionalization of various pharmaceuticals and natural products.
Authors
- Fei Pan (ORCID: https://orcid.org/0000-0002-9015-3013)
- Yan Li Jiang (ORCID: https://orcid.org/0000-0001-7665-1174)
- Yi Zhao (ORCID: https://orcid.org/0000-0003-2555-2154)
- You-Zhi Liao
Institutions
- Sichuan Normal University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-02-03
- DOI
- https://doi.org/10.1021/acs.orglett.4c04220
- Citations
- 8
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 6.33