Enabling Targeted Drug Delivery for Treatment of Ulcerative Colitis with Mucosal‐Adhesive Photoreactive Hydrogel
Ulcerative colitis (UC) is a chronic inflammatory bowel disease. UC treatments are limited by significant adverse effects associated with non-specific drug delivery, such as systematic inhibition of the host immune system. Endoscopic delivery of a synthetic hydrogel material with biocompatible gelation that can efficiently cover irregular tissue surfaces provides an effective approach for targeted drug delivery at the gastrointestinal (GI) tract. An ideal integration of synthetic material with intestinal epithelium entails an integrated and preferable chemically bonded interface between the hydrogel and mucosal surface. In this study, a photo-triggered coupling reaction is leveraged as the crosslinking platform to develop a mucosal-adhesive hydrogel, which is compatible with endoscope-directed drug delivery for UC treatment. The results demonstrated superior spatiotemporal specificity and drug pharmacokinetics with this delivery system in vivo. Delivery of different drugs with the hydrogel leads to greatly enhanced therapeutic efficacy and significantly reduced systemic drug exposure with rat colitis models. The study presents a strategy for targeted and persistent drug delivery for UC treatment.
Authors
- Lifeng Chen (ORCID: https://orcid.org/0000-0003-2580-928X)
- Bingkun Bao (ORCID: https://orcid.org/0009-0008-2710-8843)
- Linyong Zhu (ORCID: https://orcid.org/0000-0002-0398-7213)
- Wu Wen (ORCID: https://orcid.org/0000-0003-4074-7670)
- Yongzhi Yang (ORCID: https://orcid.org/0000-0001-6912-6718)
- Xiao Qu (ORCID: https://orcid.org/0009-0009-3181-7738)
- Cheng Kong (ORCID: https://orcid.org/0000-0002-3698-991X)
- Fanying Guo
- Xiaoyang Wu (ORCID: https://orcid.org/0000-0001-6378-3207)
- Yanlei Ma (ORCID: https://orcid.org/0000-0002-0632-5258)
- Mengxin Zhou (ORCID: https://orcid.org/0000-0001-6129-3386)
- Qiuning Lin (ORCID: https://orcid.org/0000-0002-9418-9590)
- Ting Chen (ORCID: https://orcid.org/0000-0003-1244-7240)
- Jinming Li (ORCID: https://orcid.org/0000-0002-1476-3397)
- Jian Zhang (ORCID: https://orcid.org/0000-0001-7053-6992)
- Alex Hoover (ORCID: https://orcid.org/0000-0002-2368-296X)
Institutions
- East China University of Science and Technology (CN)
- Shanghai Jiao Tong University (CN)
- University of Chicago (US)
- Fudan University Shanghai Cancer Center (CN)
Publication Details
- Journal
- Advanced Science
- Published
- 2025-02-03
- DOI
- https://doi.org/10.1002/advs.202404836
- Citations
- 7
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 12.72
Funders
- Samuel Waxman Cancer Research Foundation
- Shanghai Science and Technology Development Foundation
- National Institutes of Health