High-intensity acute noise exposure causes anxiety in female rats by inducing hippocampal neuron apoptosis
Our findings indicate that acute noise exposure at 135 dB elicits anxiety-like behaviors in female rats on the third day post-exposure, with these effects persisting up to one month. This sustained anxiety is attributed to the inhibition of the PI3K-AKT signaling pathway and the subsequent activation of the apoptotic Caspase-3/BCL-2/BAX pathway, culminating in hippocampal neuron apoptosis.
Authors
- Xiaohui Di
- Hongwei Zhuang (ORCID: https://orcid.org/0009-0005-0731-5413)
- Zeguo Feng (ORCID: https://orcid.org/0000-0001-7922-5461)
- Yiting Kang (ORCID: https://orcid.org/0000-0001-9597-899X)
- You‐Qiang Song (ORCID: https://orcid.org/0000-0001-9407-2256)
- Haoyu Zhang (ORCID: https://orcid.org/0000-0001-8156-5051)
- Rui Ma (ORCID: https://orcid.org/0000-0002-9457-849X)
- Jianbao Zhang (ORCID: https://orcid.org/0000-0003-4771-8442)
- Xiaoni Wang (ORCID: https://orcid.org/0000-0003-3068-600X)
- Can Ni (ORCID: https://orcid.org/0009-0006-5029-9006)
- Fadong Zhao
Institutions
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Ecotoxicology and Environmental Safety
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1016/j.ecoenv.2025.117833
- Citations
- 4
- Primary Topic
- Noise Effects and Management
- Type
- article
- Field-Weighted Citation Impact
- 12.47
Funders
- National Natural Science Foundation of China