Innovative Formulation Platform: Paving the Way for Superior Protein Therapeutics with Enhanced Efficacy and Broadened Applications (Adv. Mater. 41/2024)
Protein Formulation In review number 2403116, Zheng Cao, Chaoyong Liu, Jing Wen, and Yunfeng Lu present the recent development and advancement of protein formulation technology. This platform utilizes versatile monomers and crosslinkers to encapsulate protein therapeutics within a thin formulation layer, leading to enhanced protein stability and activity, improved biodistribution, reduced immunogenicity, and controlled release. This technology holds significant promise for clinical translation, offering potential therapeutic applications for metabolic diseases, cancers, infectious diseases, and nervous system diseases.
Authors
- Zheng Cao (ORCID: https://orcid.org/0000-0002-9147-5540)
- Jing Wen (ORCID: https://orcid.org/0000-0002-6127-6276)
- Yunfeng Lu (ORCID: https://orcid.org/0000-0002-8589-0297)
- Chaoyong Liu (ORCID: https://orcid.org/0000-0002-0914-687X)
Institutions
- University of California, Los Angeles (US)
- Black AIDS Institute (US)
- Beijing University of Chemical Technology (CN)
Publication Details
- Journal
- Advanced Materials
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1002/adma.202470326
- Citations
- 1
- Primary Topic
- Transgenic Plants and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.39