Cervical Lymph Node Invasion in Pediatric Salivary Gland Malignancies: Clinical Overview and Therapeutic Implications
This international multi-institutional study analyzed the clinical presentation and the cervical pattern of relapse of 82 pediatric patients with newly diagnosed salivary gland malignancies. Overall, nodal invasion was rare at diagnosis and only noted in 7%. In addition, 6% developed nodal relapse during follow-up. Incidence of nodal spread was frequent in mammary analogue secretory carcinoma (MASC). The overall outcome was promising with a tailored locoregional multidisciplinary approach. Systematic lymph node dissection should be reconsidered in pediatric salivary gland tumors.
Authors
- Éric Thébault (ORCID: https://orcid.org/0000-0003-1327-3852)
- N. Teissier (ORCID: https://orcid.org/0000-0003-1050-1346)
- Matthieu Carton (ORCID: https://orcid.org/0000-0002-6793-3273)
- Brice Fresneau (ORCID: https://orcid.org/0000-0001-7603-7828)
- Linda Haroun
- Cécile Faure‐Conter (ORCID: https://orcid.org/0000-0002-4717-4943)
- C. Richard (ORCID: https://orcid.org/0000-0002-0001-7879)
- Sylvie Helfré (ORCID: https://orcid.org/0000-0002-6625-3954)
- Anthony M. Sheyn (ORCID: https://orcid.org/0000-0001-5924-3689)
- Nicolás André (ORCID: https://orcid.org/0000-0002-6786-4968)
- Daniel Orbach (ORCID: https://orcid.org/0000-0002-2520-139X)
- Sara Helmig (ORCID: https://orcid.org/0000-0002-7059-5869)
- Inbal Hazkani (ORCID: https://orcid.org/0000-0002-8816-7141)
- Jeffrey C. Rastatter (ORCID: https://orcid.org/0000-0002-0168-549X)
- Vincent Couloigner (ORCID: https://orcid.org/0000-0002-6480-5903)
- Michael Houston (ORCID: https://orcid.org/0000-0002-1951-084X)
Institutions
- Université Paris-Sud (FR)
- Northwestern University (US)
- Hôpital Necker-Enfants Malades (FR)
- Lurie Children's Hospital (US)
- Centre National de la Recherche Scientifique (FR)
- St. Jude Children's Research Hospital (US)
- Inserm (FR)
- University of Tennessee Health Science Center (US)
- Université Paris Cité (FR)
- Aix-Marseille Université (FR)
- Université Paris Sciences et Lettres (FR)
- Université Paris-Saclay (FR)
- Institut Gustave Roussy (FR)
- Institut d’Hématologie et d’Oncologie Pédiatrique (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Centre de recherche en Epidémiologie et Santé des Populations (FR)
- Hôpital Robert-Debré (FR)
- Centre Oscar Lambret (FR)
- Le Bonheur Children's Hospital (US)
- Hôpital de la Timone (FR)
- Institut Curie (FR)
Publication Details
- Journal
- Pediatric Blood & Cancer
- Published
- 2025-02-03
- DOI
- https://doi.org/10.1002/pbc.31581
- Primary Topic
- Salivary Gland Tumors Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00