Immune-metabolic shifts in acute liver failure caused by HEV infection during pregnancy and their association with obstetric outcomes
HEV infection reduces choline, phosphocholine, and palmitoyl carnitine, enhancing inflammation in ALF-E, while increasing taurocholic and taurochenodeoxycholic acids impairs the immune response. These factors together likely contribute to severe obstetric complications, including higher failed inductions, intrauterine death, and maternal and fetal mortality in ALF-E.
Authors
- Anoushka Saxena
- Prabhjyoti Pahwa
- Shiv Kumar Sarin (ORCID: https://orcid.org/0000-0002-0544-5610)
- Jayesh Kumar Sevak (ORCID: https://orcid.org/0000-0003-2725-5516)
- Nirupma Trehanpati (ORCID: https://orcid.org/0000-0002-6109-0033)
- Jaswinder Singh Maras (ORCID: https://orcid.org/0000-0003-3938-362X)
- Hamda Siddiqui
- Shakun Tyagi (ORCID: https://orcid.org/0000-0002-2462-4024)
- Y. M. Mala
- Minal
Institutions
- Maulana Azad Medical College (IN)
- Institute of Liver and Biliary Sciences (IN)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1097/hc9.0000000000000608
- Citations
- 1
- Primary Topic
- Hepatitis Viruses Studies and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.32