A fatal case of chronic <i>Cryptococcus neoformans</i> meningitis progressing over a 4-year period following cladribine therapy
This case adds valuable knowledge to our current understanding of CM due to the unusual time course and furthermore demonstrates important pitfalls associated with cryptococcosis in HIV-negative patients, including the atypical disease presentation and diagnostic challenges which resulted in a diagnostic delay of 3 years. Morbidity and mortality remain high, and with a growing population of non-HIV immunocompromised patients, increased awareness of CM and low threshold to screen these patients for CrAg are warranted.
Authors
- Jannik Helweg‐Larsen (ORCID: https://orcid.org/0000-0001-7192-0144)
- Jon Gitz Holler (ORCID: https://orcid.org/0000-0001-6101-6821)
- Karen Marie Thyssen Astvad (ORCID: https://orcid.org/0000-0002-4651-2904)
- Christina Ekenberg (ORCID: https://orcid.org/0000-0003-0137-4269)
- Christian Stenør (ORCID: https://orcid.org/0000-0002-3314-2334)
- Micha Phill Grønholm Jepsen
Institutions
- Statens Serum Institut (DK)
- Copenhagen University Hospital (DK)
- Gentofte Hospital (DK)
- Rigshospitalet (DK)
- Zealand University Hospital (DK)
Publication Details
- Journal
- ASM Case Reports
- Published
- 2025-02-03
- DOI
- https://doi.org/10.1128/asmcr.00061-24
- Primary Topic
- Fungal Infections and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00