Fibroblast growth factor receptor 3 mutation promotes HSPB6-mediated cuproptosis in hypochondroplasia by impairing chondrocyte autophagy
We first demonstrate that impaired autophagy and enhanced cuproptosis are pivotal in the pathogenesis of HCH. This study not only enlarged the therapeutic potential of targeting cuproptosis for treating <i>FGFR3</i> mutation-related HCH but also provided a novel perspective on the role of the HSPB6-ERK-Drp1-FDX1 signaling pathway in the development of HCH. Consequently, this article provides valuable insights into the mechanisms and treatment strategies for <i>FGFR3</i> mutation-related chondrodysplasia.
Authors
- Dan He (ORCID: https://orcid.org/0000-0002-0118-3625)
- Lin Che (ORCID: https://orcid.org/0009-0005-2619-9382)
- Baohong Shi (ORCID: https://orcid.org/0000-0002-5099-9233)
- Ren Xu (ORCID: https://orcid.org/0000-0001-6578-4553)
- C. NIU (ORCID: https://orcid.org/0000-0003-0727-5763)
- Na Li (ORCID: https://orcid.org/0000-0002-4112-0944)
- Chengrun Yuan
- Jiangfei Yang
- Liangkai Zheng (ORCID: https://orcid.org/0009-0001-5321-2715)
- Jing Chen (ORCID: https://orcid.org/0000-0003-0676-1794)
Institutions
- Sun Yat-sen University (CN)
- Xiamen University (CN)
- Princess Margaret Hospital for Children (AU)
- Shandong Provincial Hospital (CN)
- Sun Yat-sen University Cancer Center (CN)
- Children’s Hospital of Fudan University Xiamen Branch (CN)
- Shandong First Medical University (CN)
- Xiamen Maternal and Child Health Hospital (CN)
Publication Details
- Journal
- Journal of Orthopaedic Translation
- Published
- 2025-02-03
- DOI
- https://doi.org/10.1016/j.jot.2025.01.011
- Citations
- 4
- Primary Topic
- Connective tissue disorders research
- Type
- article
- Field-Weighted Citation Impact
- 7.27
Funders
- National Natural Science Foundation of China