Rapid Quantitative Assessment of Muscle Sodium Dynamics After Exercise Using <sup>23</sup>Na‐MRI in Dysferlinopathy and Healthy Controls
Assessment of TA muscle fat fraction, <sup>1</sup>H T<sub>2</sub>, sodium content and sodium T<sub>2</sub>* relaxation properties revealed differences at baseline and in post-exercise dynamics between patients with dysferlinopathy and matched controls. Post-exercise <sup>23</sup>Na recovery dynamics followed a well-defined time course in HV. Heterogeneous alterations in sodium content and MR relaxation properties in DP may reflect altered ion homeostasis associated with chronic muscle damage.
Authors
- Volker Straub (ORCID: https://orcid.org/0000-0001-9046-3540)
- Mark T. Richardson (ORCID: https://orcid.org/0000-0003-3431-916X)
- M. James (ORCID: https://orcid.org/0000-0001-8078-7744)
- Ian Wilson (ORCID: https://orcid.org/0000-0001-6893-2873)
- Carla Bolano-Diaz
- Peter E. Thelwall (ORCID: https://orcid.org/0000-0003-1795-6394)
- J. Michell-Sodhi
- Mary Neal (ORCID: https://orcid.org/0000-0002-5634-7586)
- Robert Muni‐Lofra (ORCID: https://orcid.org/0000-0002-8901-9140)
- Jordi Díaz‐Manera (ORCID: https://orcid.org/0000-0003-2941-7988)
- Andrew M. Blamire (ORCID: https://orcid.org/0000-0002-8749-1257)
- H. Hilsden
- Kieren G. Hollingsworth
Institutions
- Instituto de Salud Carlos III (ES)
- Newcastle upon Tyne Hospitals NHS Foundation Trust (GB)
- Hospital de Sant Pau (ES)
- Centre for Biomedical Network Research on Rare Diseases (ES)
- Instituto de Investigación de Enfermedades Raras (ES)
- Newcastle University (GB)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/jcsm.13709
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jain Foundation
- National Institute for Health and Care Research
- NIHR Newcastle Biomedical Research Centre