Smooth muscle cell Piezo1 is essential for phenotypic switch and neointimal hyperplasia
These findings demonstrate a critical role of mechanosensitive Piezo1 channel in neointimal hyperplasia via modulating VSMC phenotype. Piezo1 channels may represent a novel therapeutic target for maladaptive vascular remodelling and occlusive vascular diseases.
Authors
- Qingqing Lei
- Jie Tang (ORCID: https://orcid.org/0000-0002-3991-2539)
- Zhuomiao Lin
- Jing‐Song Ou
- Shiqi Mo
- Xiao‐Fei Lv
- F. Zhang
- Andong Zhou (ORCID: https://orcid.org/0009-0008-4383-7173)
- Cheng Wang (ORCID: https://orcid.org/0000-0002-1590-7954)
- Rui‐Ping Pang
- Cong‐Cong Han
- Jia‐Guo Zhou (ORCID: https://orcid.org/0000-0003-1218-7565)
- Ying Lai
Institutions
- Sun Yat-sen University (CN)
- Guangdong Medical College (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Fifth Affiliated Hospital of Sun Yat-sen University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-02-03
- DOI
- https://doi.org/10.1111/bph.17436
- Citations
- 7
- Primary Topic
- Erythrocyte Function and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 8.15
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- National Key Research and Development Program of China