Multi-centre data harmonisation applied to heart-to-mediastinum quantification in parkinsonism (ITA-MIBG): a cross-calibration phantom study with tube and bottle

Abstract Purpose Planar cardiac scintigraphy with [ 123 I]I-mIBG is widely used to image myocardial sympathetic activity. In multicentre studies, different γ-cameras can cause variability in quantitative parameters. This study aimed to harmonise multicentre [ 123 I]I-mIBG data using a custom-designed phantom and to assess its feasibility and acceptability. Methods A ‘tube and bottle’ phantom was designed to standardise the heart-to-mediastinum (H/M) ratio across 15 centres. Each centre prepared three versions of the phantom (A, B, and C) with varying pertechnetate ([ 99m Tc]Tc-O4-) activities, acquired static images using their own γ-camera, and uploaded DICOM data to a shared platform. In the phantom, the tube and bottle represent the heart and mediastinum, respectively, with the tube-to-bottle (T/B) ratio simulating the H/M ratio. The reference centre analysed the images and calculated the T/B ratios, applying linear regression for data harmonisation. A survey was conducted to assess the phantom’s usability. Results The harmonised T/B ratios for versions A and B were 20.46 ± 0.78 and 6.19 ± 0.39, respectively. The average slope and intercept of the regression line across the participating centres resulted in 1.07 ± 0.38 and − 0.82 ± 4.95. Survey feedback indicated high feasibility and acceptability, with all centres recommending the phantom for multicentre harmonisation. Conclusions The custom-made phantom effectively harmonised experimental data across different centres, supporting its use in multicentre studies to improve data consistency.

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Publication Details

Journal
Clinical and Translational Imaging
Published
2025-02-03
DOI
https://doi.org/10.1007/s40336-025-00681-4
Primary Topic
Advanced MRI Techniques and Applications
Type
article
Field-Weighted Citation Impact
0.00

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article

Multi-centre data harmonisation applied to heart-to-mediastinum quantification in parkinsonism (ITA-MIBG): a cross-calibration phantom study with tube and bottle

Viviana Frantellizzi, Matteo Minestrini, Achille Lazzarato, Francesco Bianconi et al.
Clinical and Translational Imaging
Advanced MRI Techniques and Applications
article

Multi-centre data harmonisation applied to heart-to-mediastinum quantification in parkinsonism (ITA-MIBG): a cross-calibration phantom study with tube and bottle

Viviana Frantellizzi, Matteo Minestrini, Achille Lazzarato, Francesco Bianconi, Angela Spanu, Maria Gazzilli, Giuseppe De Vincentis, Luca Filippi, Oreste Bagni, Daniela D’Ambrosio, Andrea Marongiu, Cristina Ferrari, Barbara Palumbo, Massimiliano Casali, Priscilla Guglielmo, Gayanè Aghakhanyan, Stefano Panareo, Francesco Bertagna, Orazio Schillaci, Laura Evangelista, Alessia Giordano
article en

Abstract

Abstract Purpose Planar cardiac scintigraphy with [ 123 I]I-mIBG is widely used to image myocardial sympathetic activity. In multicentre studies, different γ-cameras can cause variability in quantitative parameters. This study aimed to harmonise multicentre [ 123 I]I-mIBG data using a custom-designed phantom and to assess its feasibility and acceptability. Methods A ‘tube and bottle’ phantom was designed to standardise the heart-to-mediastinum (H/M) ratio across 15 centres. Each centre prepared three versions of the phantom (A, B, and C) with varying pertechnetate ([ 99m Tc]Tc-O4-) activities, acquired static images using their own γ-camera, and uploaded DICOM data to a shared platform. In the phantom, the tube and bottle represent the heart and mediastinum, respectively, with the tube-to-bottle (T/B) ratio simulating the H/M ratio. The reference centre analysed the images and calculated the T/B ratios, applying linear regression for data harmonisation. A survey was conducted to assess the phantom’s usability. Results The harmonised T/B ratios for versions A and B were 20.46 ± 0.78 and 6.19 ± 0.39, respectively. The average slope and intercept of the regression line across the participating centres resulted in 1.07 ± 0.38 and − 0.82 ± 4.95. Survey feedback indicated high feasibility and acceptability, with all centres recommending the phantom for multicentre harmonisation. Conclusions The custom-made phantom effectively harmonised experimental data across different centres, supporting its use in multicentre studies to improve data consistency.

Clinical and Translational ImagingVol. 13(2)
University of Pisa (IT), University of Rome Tor Vergata (IT), University of Modena and Reggio Emilia (IT), Humanitas University (IT), University of Sassari (IT), University of Perugia (IT), Azienda Unita' Sanitaria Locale Di Modena (IT), Istituti Clinici Scientifici Maugeri (IT), Centro di Riferimento Oncologico della Basilicata (IT), Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT), Azienda Unità Sanitaria Locale Piacenza (IT), Humanitas Gavazzeni (IT), Ospedale Santa Maria Goretti (IT), IRCCS Humanitas Research Hospital (IT), Azienda Ospedaliera G. Brotzu (IT), University of Bari Aldo Moro (IT), University of Brescia (IT), Sapienza University of Rome (IT)
Università degli Studi di Roma Tor Vergata
Openalex Percentile: Top 97%
Advanced MRI Techniques and Applications
DOIOpen Access PDFOpenAlex
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