Identification of clonally expanded T-cell receptor sequences in giant cell arteritis
Our data provide evidence of circulating T-cell clonal expansions in GCA patients. Certain TCR sequence patterns were over-represented in GCA subjects. As more TCR sequences directed at human antigens become available, further analysis may ultimately reveal whether these TCRs bind a common target antigen.
Authors
- María Rodríguez Martínez (ORCID: https://orcid.org/0000-0003-3766-4233)
- Ann W Morgan (ORCID: https://orcid.org/0000-0003-1109-624X)
- Darren James Newton (ORCID: https://orcid.org/0000-0002-0214-1486)
- Lubna Haroon‐Rashid
- Alice Driessen (ORCID: https://orcid.org/0000-0002-8822-2606)
- Anna Weber (ORCID: https://orcid.org/0000-0003-3200-8210)
- Michal Zulcinski (ORCID: https://orcid.org/0000-0003-4570-1882)
- Beth Kuszlewicz
Institutions
- University of Leeds (GB)
- Board of the Swiss Federal Institutes of Technology (CH)
- Leeds Teaching Hospitals NHS Trust (GB)
- Yale University (US)
- IBM Research - Zurich (CH)
Publication Details
- Journal
- Journal of Autoimmunity
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1016/j.jaut.2025.103372
- Primary Topic
- Vasculitis and related conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Medical Research Council