The novel role of LCK and other PcDEGs in the diagnosis and prognosis of sepsis: Insights from bioinformatic identification and experimental validation
Our study reveals that PcDEGs are dysregulated in sepsis, and closely related to disease pathology. Our finding provides new insights into clinical identification and outcome prediction of sepsis. Of note, LCK is a new biomarker for diagnosis and prognosis, which might be a potential therapeutic target for the treatment of sepsis.
Authors
- Lunxian Tang
- Li Shao
- Jiani Xu (ORCID: https://orcid.org/0009-0006-9644-1354)
- Yuxin Zhu
- Jinlu Ji
- Kun Chen
- Xiandong Liu
- Xiaohui Zhou (ORCID: https://orcid.org/0000-0002-9354-3789)
- Min Yang (ORCID: https://orcid.org/0000-0002-9034-3175)
- Qian Yang (ORCID: https://orcid.org/0009-0002-1051-2475)
- Chunxue Wang (ORCID: https://orcid.org/0000-0003-3154-0985)
- Bingrui Ling
- Fanyu Kong
Institutions
- Tongji University (CN)
- Anhui Medical University (CN)
- Shanghai East Hospital (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2025-02-03
- DOI
- https://doi.org/10.1016/j.intimp.2025.114194
- Citations
- 3
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.06