Evaluating lipid-lowering drug targets for full-course diabetic retinopathy
This study reveals PPARG may be a promising drug target for full-course DR. The activation of PPARG could reduce the risk of full-course DR, especially background DR and PDR. The mechanism of the PPARG agonists' protection of full-course DR may be dependent on the glucose-lowering effect.
Authors
- Zhuoting Zhu (ORCID: https://orcid.org/0000-0002-9897-1192)
- Zijing Du (ORCID: https://orcid.org/0000-0002-8676-8293)
- Qiaowei Wu (ORCID: https://orcid.org/0000-0001-9454-1411)
- Chunran Lai
- Ting Su (ORCID: https://orcid.org/0000-0001-8606-4627)
- Qin‐Yi Li (ORCID: https://orcid.org/0000-0003-1388-7686)
- Yu Huang (ORCID: https://orcid.org/0000-0002-3875-7581)
- Honghua Yu (ORCID: https://orcid.org/0000-0002-0782-346X)
- Xiayin Zhang (ORCID: https://orcid.org/0000-0003-0250-0247)
- Kaiyi Chi (ORCID: https://orcid.org/0000-0002-1872-6323)
- Yijun Hu (ORCID: https://orcid.org/0000-0002-6424-7905)
- Yunyan Hu
- Shan Wang (ORCID: https://orcid.org/0000-0002-0862-4681)
- Shuilian Chen (ORCID: https://orcid.org/0009-0005-9532-4730)
- Ying Fang (ORCID: https://orcid.org/0000-0001-7515-837X)
- Jiahui Cao
Institutions
- Centre for Eye Research Australia (AU)
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- British Journal of Ophthalmology
- Published
- 2025-02-03
- DOI
- https://doi.org/10.1136/bjo-2024-325771
- Citations
- 6
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 10.24
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Guangdong Provincial People's Hospital
- Basic and Applied Basic Research Foundation of Guangdong Province