HINT1 suppression protects against age-related cardiac dysfunction by enhancing mitochondrial biogenesis
Our findings suggest that mitochondrial biogenesis in cardiomyocytes decreases with age and could underlie cardiac dysfunction, and that the Caren-HINT1-mitochondrial biogenesis axis may constitute a mechanism linking CR to resistance to cardiac aging. We also show that ameliorating declines in mitochondrial biogenesis in cardiomyocytes could counteract age-related declines in cardiac function, and that this strategy may improve exercise tolerance and extend so-called "healthy life span".
Authors
- Yuya Kinoshita (ORCID: https://orcid.org/0000-0001-8695-2501)
- Daisuke Torigoe (ORCID: https://orcid.org/0009-0007-9924-4994)
- Tsuyoshi Kadomatsu (ORCID: https://orcid.org/0000-0003-3327-6954)
- Yuichi Oike (ORCID: https://orcid.org/0000-0003-3245-5395)
- Shuji Yamamura
- Sumio Ohtsuki (ORCID: https://orcid.org/0000-0003-4634-7133)
- Kimi Araki (ORCID: https://orcid.org/0000-0002-1396-1527)
- Koichi Node (ORCID: https://orcid.org/0000-0002-2534-0939)
- Haruki Horiguchi (ORCID: https://orcid.org/0000-0001-9344-8362)
- Goro Yoshioka (ORCID: https://orcid.org/0000-0002-3735-9258)
- Tomohiko Wakayama (ORCID: https://orcid.org/0000-0002-8795-7950)
- Keishi Miyata (ORCID: https://orcid.org/0000-0003-0336-1859)
- Michio Sato (ORCID: https://orcid.org/0000-0001-9339-1642)
- Jun Morinaga (ORCID: https://orcid.org/0000-0002-6196-6023)
- Ryoko Kusaba
- Takanori Yamaguchi (ORCID: https://orcid.org/0000-0001-5732-4311)
Institutions
- Kumamoto Health Science University (JP)
- Saga University (JP)
- Kumamoto University (JP)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-02-03
- DOI
- https://doi.org/10.1016/j.molmet.2025.102107
- Citations
- 5
- Primary Topic
- Genetics and Neurodevelopmental Disorders
- Type
- article
- Field-Weighted Citation Impact
- 9.09
Funders
- Naito Foundation
- Takeda Science Foundation
- Novartis Foundation
- Japan Agency for Medical Research and Development
- Ministry of Education, Culture, Sports, Science and Technology
- Ichiro Kanehara Foundation for the Promotion of Medical Sciences and Medical Care
- Japanese Circulation Society
- Mochida Memorial Foundation for Medical and Pharmaceutical Research
- SENSHIN Medical Research Foundation
- NOVARTIS Foundation (Japan) for the Promotion of Science
- Japan Heart Foundation
- Core Research for Evolutional Science and Technology