The Current Status of Tumor Markers as Biomarkers in the Era of Immunotherapy for Hepatocellular Carcinoma: Alpha-Fetoprotein Alone Is Not Sufficient
Based on introduction of systemic treatment in an early stage and increasing numbers of HCC cases with a nonviral etiology, the positive rate of AFP level has been declining. Thus, determination of DCP and AFP-L3 in addition to AFP as markers should be more actively utilized in clinical practice, as well as clinical trials for monitoring and evaluating treatment response in this era of combination immunotherapy as a powerful treatment.
Authors
- Hideko Ohama (ORCID: https://orcid.org/0000-0002-1882-824X)
- Norio Itokawa (ORCID: https://orcid.org/0009-0002-2390-6692)
- Joji Tani (ORCID: https://orcid.org/0000-0001-8801-2505)
- Kazunari Tanaka (ORCID: https://orcid.org/0000-0001-9811-2665)
- Yuki Kanayama (ORCID: https://orcid.org/0000-0002-8639-5212)
- Tomomitsu Matono
- Hidenao Noritake (ORCID: https://orcid.org/0000-0003-3649-5335)
- Kazuhito Kawata (ORCID: https://orcid.org/0000-0002-4986-8578)
- Kazuya Kariyama (ORCID: https://orcid.org/0000-0003-3996-7502)
- Hidenori Toyoda (ORCID: https://orcid.org/0000-0002-1652-6168)
- Hirayuki Enomoto (ORCID: https://orcid.org/0000-0003-1334-1149)
- Kazuhiro Nouso (ORCID: https://orcid.org/0000-0002-2018-0008)
- Takeshi Hatanaka (ORCID: https://orcid.org/0000-0003-3656-285X)
- Masatoshi Kudo (ORCID: https://orcid.org/0000-0002-4102-3474)
- Yoichi Hiasa (ORCID: https://orcid.org/0000-0003-4117-339X)
- Kunihiko Tsuji (ORCID: https://orcid.org/0009-0007-4152-9364)
- Atsushi Hiraoka (ORCID: https://orcid.org/0000-0003-1989-0480)
- Takashi Kumada (ORCID: https://orcid.org/0000-0003-2211-495X)
- Yoshiko Nakamura
- Shinya Fukunishi (ORCID: https://orcid.org/0000-0001-6930-2814)
- Tomomi Okubo (ORCID: https://orcid.org/0000-0003-1244-4736)
- Takuya Nagano (ORCID: https://orcid.org/0000-0003-1043-8033)
- Ei Itobayashi (ORCID: https://orcid.org/0000-0003-0475-2819)
- Masaki Kaibori (ORCID: https://orcid.org/0000-0002-0577-3921)
- Masashi Hirooka (ORCID: https://orcid.org/0000-0001-5634-5313)
- Chikara Ogawa (ORCID: https://orcid.org/0000-0002-4534-6692)
- Hiroki Nishikawa (ORCID: https://orcid.org/0000-0003-3489-2740)
- Hisashi Kosaka (ORCID: https://orcid.org/0000-0002-2926-9973)
- Kazuto Tajiri (ORCID: https://orcid.org/0000-0002-2373-8601)
- Takashi Nishimura (ORCID: https://orcid.org/0000-0002-5517-8303)
- Toshifumi Tada (ORCID: https://orcid.org/0000-0002-0976-6761)
- Atsushi Naganuma (ORCID: https://orcid.org/0000-0003-0663-0102)
- Akemi Tsutsui (ORCID: https://orcid.org/0000-0003-2978-2723)
- Hidekatsu Kuroda (ORCID: https://orcid.org/0000-0002-1471-1087)
- Toru Ishikawa (ORCID: https://orcid.org/0000-0002-5470-9694)
- Yutaka Yata (ORCID: https://orcid.org/0000-0002-4592-3509)
- Masanori Atsukawa (ORCID: https://orcid.org/0000-0003-3374-7111)
- Yuichi Koshiyama (ORCID: https://orcid.org/0009-0006-1247-1215)
- Tomoko Aoki (ORCID: https://orcid.org/0000-0002-9950-4553)
- Fujimasa Tada (ORCID: https://orcid.org/0009-0007-3964-5876)
- Asahiro Morishita (ORCID: https://orcid.org/0000-0002-0760-3045)
- Koichi Takaguchi (ORCID: https://orcid.org/0000-0003-0175-8721)
- Michitaka Imai (ORCID: https://orcid.org/0000-0001-6448-6036)
- Satoru Kakizaki (ORCID: https://orcid.org/0000-0003-0224-7093)
- Shinichiro Nakamura (ORCID: https://orcid.org/0009-0001-5065-9669)
- Hironori Tanaka (ORCID: https://orcid.org/0000-0001-7795-3844)
- Osamu Yoshida
- Taeang Arai
Institutions
- Kansai Medical University (JP)
- Iwate Medical University (JP)
- Kagawa University (JP)
- Hamamatsu University School of Medicine (JP)
- Takamatsu Red Cross Hospital (JP)
- Saiseikai Niigata Daini Hospital (JP)
- National Hospital Organization Takasaki Medical Center (JP)
- Okayama Prefecture (JP)
- Ogaki Municipal Hospital (JP)
- Himeji Medical Center (JP)
- Hanwa Memorial Hospital (JP)
- Gunma Saiseikai Maebashi Hospital (JP)
- Himeji Red Cross Hospital (JP)
- Teine Keijinkai Hospital (JP)
- Asahi General Hospital (JP)
- Toyama University Hospital (JP)
- Ehime Prefectural Central Hospital (JP)
- Kagawa Prefectural Central Hospital (JP)
- Takarazuka City Hospital (JP)
- Ehime University (JP)
- Gifu Kyoritsu University (JP)
- Nippon Medical School (JP)
- Hyogo University (JP)
- Osaka University of Pharmaceutical Sciences (JP)
- Kindai University (JP)
Publication Details
- Journal
- Oncology
- Published
- 2025-02-03
- DOI
- https://doi.org/10.1159/000543405
- Citations
- 2
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 2.64