Ibuprofen prevents the conjugative transfer of plasmid-mediated antimicrobial resistance genes
Refractory infections caused by multidrug-resistant bacteria pose a significant threat to public health. Here we report that ibuprofen inhibits conjugation of the RP4 plasmid and plasmids from clinical strains carrying different resistance genes including mcr-1, bla<sub>NDM</sub>, bla<sub>KPC</sub>, tet(X4), and tmexCD1-toprJ1. Mechanistic studies suggest that ibuprofen reduces ATP production and inhibits conjugation-related genes. The inhibitory effect of ibuprofen on conjugation has significant clinical implications for preventing the spread of multidrug resistance, opening new therapeutic avenues to combat multidrug-resistant bacteria.
Authors
- Yuanyuan Li (ORCID: https://orcid.org/0000-0003-4711-4294)
- Yunbing Li
- Xiaofan Li (ORCID: https://orcid.org/0000-0002-5011-6314)
- Xu Chen (ORCID: https://orcid.org/0000-0002-6288-6308)
- Guang-Fen Zhang (ORCID: https://orcid.org/0000-0002-3934-8368)
- Ning Dong (ORCID: https://orcid.org/0000-0001-6515-4201)
- Chunli Li (ORCID: https://orcid.org/0000-0001-7095-5820)
- Shuyan Wu
- Xiangkun Zeng
Institutions
- Jiangsu University (CN)
- Soochow University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Journal of Global Antimicrobial Resistance
- Published
- 2025-02-03
- DOI
- https://doi.org/10.1016/j.jgar.2025.01.012
- Citations
- 1
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.59
Funders
- China Postdoctoral Science Foundation
- Natural Science Foundation of Jiangsu Province